No News is Good News RE: Testosterone Replacement Therapy Update


I started testosterone replacement therapy at age 31 after being diagnosed with secondary hypogonadism. Researching hormone replacement therapy (HRT) with testosterone was difficult because all of the info was for women or bodybuilders. So I decided to create a site for average guys looking into TRT.

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4 Responses

  1. JM says:

    I’ve been on TRT for about 6 years now with the first few being fairly positive however, the last couple years have been pretty up and down. I’ve tried Andgrogel, Testim and now have been on Test Cyp for the last 4 years. My problem is that I can’t seem to find the right balance with my dosage and frequency in order to avoid the side effects. When my levels are higher my BP goes up above normal and I suffer from heavy water retention. Over the last couple years my body seems to aromatase the testosterone much more than in previous years. I also take Arimedex but that doesn’t seem to help with my side effects and based on my labs my estrogen is way below normal so what your endo describes about what Adex can do when you’re on long term TRT sounds like exactly what I’m going through. I’ve never tried Nolvedex but I think I will ask my endo if he will prescribe it to me. A few years I did ask about Nolvedex vs. Adex and he said he preferred Adex because it is a aromatase inhibitors. However, quite frankly I don’t think he knows all that much about long term TRT. He’s a good Dr but I think he deals with much more Diabetes patients than men on TRT. Thanks for the post, it’s always hard to find good info on long term TRT! I will check back after I’ve had the opportunity to try Nolvadex for a while.

    • TRT Man says:

      JM the problem with Adex is that it stops your body from aromatizing, but it doesn’t stop whatever messages are telling the body to aromatize so it builds up over time. The endocrine system has many feedback systems. For example, when my thyroid hormone is too low my body produces more thyroid stimulating hormone (TSH). Thus “high TSH” means “low TH”. If I had a healthy thyroid but was taking something that would block thyroid hormone from being made my body would produce more and more TSH to try and get more TH made. My TSH levels would be through the roof after awhile and when I eventually stopped taking whatever was blocking the TH from being made suddenly I’d be producing way too much TH because of the skyrocketed TSH levels.

      What I like about Nolvadex is the estrogen continues to be made, but is just blocked from the receptors where it would normally park and cause issues like Gyno.

      I’m sorry to hear about your problems. I’ve been on for about 3.5 years now and I’m starting to notice a few issues too. My PSA levels are getting high, as are my red bloodcell count. So now I’m at a higher risk of prostate cancer, stroke, heart attack, etc.. Part of me wants to try to come off testosterone again, but I’m not sure I could deal with it. I really do like being on testosterone. If only we could do so without side effects. 😉

  2. dean says:

    Is there anyway to email you? Starting this journey and had a couple of questions about the process. Glad I found this site!

    • TRT Man says:

      Sorry Dean I try to keep my anonymity on here due to the sensitive subject matter of the blog. Feel free to ask any questions you have though!